A：Because the high-voltage pulses of traditional IRE technology stimulate nerves and trigger tetanic muscle contractions, muscle relaxants combined with endotracheal intubation and general anesthesia are mandatory, resulting in high surgical risk and limited scenarios. Winonco’s team overcame this pain point through broadband synergistic high-voltage pulse technology, making it impossible for human nerves to produce an effective response, automatically completing physiological filtering, and blocking the cumulative neuromuscular response. Large-animal experiments confirmed that after WKnife treatment, almost no obvious muscle contraction acceleration can be detected. This original breakthrough enabled IRE ablation to leap from “general anesthesia” to “local anesthesia,” allowing the procedure to be performed in an outpatient setting and greatly lowering the threshold and cost.

A：WKnife is a new-generation IRE technology product independently developed by Winonco, and it represents a generational gap compared with previous-generation microsecond-pulse technologies such as the imported NanoKnife:

① Anesthesia method: WKnife supports local anesthesia, whereas the previous-generation technology requires general anesthesia with intubation;

② Electrode design: WKnife supports single-needle operation, whereas the previous-generation technology requires multiple needles in parallel alignment; WKnife greatly reduces the difficulty of operation;

③ WKnife does not require ECG synchronization;

④ Supports needle-tract management;

⑤ Superior immunological response.