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One Needle Ablates Three Lesions | The First Affiliated Hospital of Jinan University Completes Wknife Ablation of Multiple Liver Metastases from Ovarian Cancer

2026-09-30

Recently, the Department of Interventional Vascular Surgery of the First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital) used Wknife to complete an ablation procedure for liver metastatic lesions from ovarian cancer.




The patient in this procedure was Ms. H, 53 years old, diagnosed with stage IIIC ovarian intestinal-type adenocarcinoma. She had previously undergone robot-assisted cytoreductive surgery for ovarian malignant tumor at the First Affiliated Hospital of Jinan University — total hysterectomy, bilateral adnexectomy, pelvic and para-aortic lymph node dissection, and resection of the greater omentum, appendix, retroperitoneal mass, and abdominal wall tumor; part of the liver lesion was also resected during the same procedure. After such a major operation that “practically went through the entire abdominal cavity,” she received regular chemotherapy and completed seven cycles.

However, the latest contrast-enhanced MRI was not encouraging: multiple intrahepatic nodules were judged on imaging to be metastatic lesions — the lesions in segments S6 and S7 had enlarged compared with before, while the S2 lesion was similar to before. Chemotherapy had not stopped the progression in the liver.

At this point, Ms. H’s physical condition no longer allowed another major surgery: post-chemotherapy myelosuppression, abnormal liver function indicators, and comorbid hypertension. Her treatment path had reached a dilemma of “the tumor is progressing while the body is sending alarm signals.”

What was even more challenging was the location of the lesions: the S6 lesion was close to the liver capsule, while the S7 lesion was located in the angle between the right hepatic vein and the inferior vena cava, tightly adjacent to the diaphragm — the lesions were in awkward locations and were scattered from one another. Treating any one of them could not injure the “neighbors,” and complete coverage of all three still had to be ensured.

After comprehensive departmental evaluation, Ms. H did not meet the conditions for another major surgery, and chemotherapy had also reached a bottleneck. It was therefore decided to use local ablation to treat the progressing intrahepatic lesions.



Procedure: Single Needle Under Local Anesthesia — Completed Smoothly


The procedure was performed by Deputy Director Jiang Xiangwu of the Department of Interventional Vascular Surgery, using local anesthesia: subcutaneous injection of lidocaine for local infiltration, supplemented by intramuscular pethidine for analgesia — no “major anesthesia,” no intubation, and the patient remained awake throughout.

The core of the procedure lay in “one needle traveling throughout.” Under image guidance, Director Jiang punctured the Wknife integrated bipolar single needle into the first lesion, placed the needle, ablated, and withdrew the needle, then adjusted the angle and depth to enter the second and third lesions — the three lesions were distributed in different parts of the liver, with different needle insertion routes, and a single needle precisely reached each one in turn, completing ablation one after another.


It is worth mentioning the management of two “high-risk neighbors”: for the lesion close to the liver capsule, the needle tip was precisely positioned against the inner side of the capsule, with the ablation boundary fitting tightly; for the lesion tightly adjacent to the diaphragm, the ablation process was stable, the patient tolerated it well throughout, and there was no obvious pain response.


The entire ablation process took about 20 minutes, and together with preoperative preparation, the total procedure time was about one hour. The patient recovered smoothly after the procedure.



Operator's Comment



“The S7 lesion is located in the angle between the right hepatic vein and the inferior vena cava, tightly adjacent to the diaphragm, and is almost a forbidden zone for conventional percutaneous ablation. Whether radiofrequency, microwave, or argon-helium cryoablation, all carry great risks of diaphragmatic injury and incomplete ablation,” said Deputy Chief Physician Jiang Xiangwu after the procedure.

“Wknife, however, is non-thermal ablation and does not have the ‘heat-sink effect’ — the heat generated by ablation will not be carried away by the blood flow of large intrahepatic vessels, so there is no fear of residual tumor due to incomplete ablation beside vessels; at the same time, it is relatively friendly to collagen structures such as blood vessels, bile ducts, and the diaphragm, and there is no concern that energy will damage surrounding important tissues. One can confidently use an 18G ablation needle tip to penetrate the tumor and approach the diaphragm for ablation. Its single-needle ablation range is large enough, and a multi-needle array is not needed. The operation is very simple, and the entire procedure is performed under local anesthesia, so there is no need to consider anesthesia risk and anesthesia costs are saved. It makes one marvel at how rapidly science and technology are advancing, turning many impossible things into possible and benefiting humanity.”


Clinical Value



First, the single-needle ablation range is large enough for one needle to treat three lesions. Conventional ablation of one lesion often requires one needle and one array; multiple lesions mean multiple needles in parallel or staged procedures. Wknife’s single-needle ablation range is considerable, and one needle can flexibly switch between different sites; the three lesions were treated with needle insertion as needed and completed in one session. The operation is simple, and the number of punctures is greatly reduced — and the risk of bleeding and injury is reduced accordingly.

Second, the non-thermal mechanism solves the chronic problem of “difficult ablation beside blood vessels.” Thermal ablation in areas with dense blood vessels is prone to incomplete ablation because blood flow “carries away heat,” and there is also concern that heat may affect important structures such as blood vessels, bile ducts, and the diaphragm. Irreversible electroporation does not rely on thermal effects and is friendly to vascular structures, making it possible to “safely treat lesions hugging blood vessels and the diaphragm.”

Third, completing ablation under local anesthesia opens a door for patients whose treatment has reached a bottleneck. The local anesthesia protocol does not require intubation or general anesthesia, reducing anesthesia risk and recovery burden to a minimum, so that “the body cannot withstand major surgery” no longer equals “there is nothing that can be done.”


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Expert Introduction


Li Chengzhi, The First Affiliated Hospital of Jinan University

Chief Physician, Associate Professor, MD, Doctoral Supervisor, Postdoctoral Co-supervisor, Director of the Department of Interventional Vascular

Surgery, Director of the Diabetic Foot Diagnosis and Treatment Center, Deputy

Director of the Yttrium-90 Liver Tumor Interventional Treatment Center



Visiting Scholar, Beth Israel Deaconess Medical Center, Harvard Medical School, USA; Visiting Scholar, Bardkrozingen Cardiovascular Treatment Center, University

of Freiburg, Germany; published more than 30 SCI articles; responsible for 1 national-level project

and 4 Guangdong provincial science and technology projects; currently Chairman of the Interventional and Vascular

Surgery Professional Committee of the Guangdong Provincial Association for the Elderly Health Care;

Vice Chairman of the Interventional Branch of the Guangdong Hospital Management Association;

Vice Chairman of the Precision Intervention Branch of the Guangdong Precision Medicine Application Society;

Vice Chairman of the Vascular Surgery Branch of the Guangzhou Medical Doctor Association;

Vice Chairman of the Peripheral Vascular Disease Branch of the Guangdong Precision Medicine Application Society;

Vice Chairman of the Portal Hypertension Prevention and Treatment Professional Committee of the Guangdong Health Management Association;

Standing Committee Member of the Liver Cancer Integrated Treatment Committee of the Chinese Anti-Cancer Association;

Standing Committee Member of the Vascular Surgery Branch of the Guangdong Medical Doctor Association;

Standing Committee Member of the Interventional Branch of the Guangdong Medical Doctor Association;

Standing Committee Member of the Interventional Branch of the Guangdong Medical Association;

Standing Committee Member of the Vascular Disease Diagnosis and Treatment Committee of the Guangdong Hospital Management Association and member of multiple other societies;

Engaged in peripheral vascular and tumor interventional treatment for more than 10 years.


Jiang Xiangwu

Deputy Chief Physician, Department of Interventional Vascular Surgery, The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital); one of the earlier physicians in China to engage in minimally invasive tumor ablation; has performed nearly 10,000 tumor ablation procedures over more than 20 years; published more than 10 clinical papers on tumor ablation in Chinese medical journals in the Chinese Medical Association series and in SCI-indexed journals.



Member of the World Tumor Ablation Association (WTAA);

Member of the Chinese Anti-Cancer Association (CACA);

Member of the Comprehensive Treatment Committee of the Guangdong Liver Disease Society;

Member of the Ultrasonic Endoscopy Society of the Guangdong Medical Association.


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About winonco


Hangzhou winonco Medical Technology Co., Ltd. is a National High-Tech Enterprise whose mission is to deliver innovative minimally invasive tumor ablation solutions. With fully self-developed high-voltage pulsed electric field irreversible electroporation (IRE) technology at its core and covering a multi-physics, multi-modal technology platform, the company develops internationally leading minimally invasive tumor ablation solutions.

The company was founded by scientists who returned from Europe and the United States and by national-level talent scientists, and it has a high-level multidisciplinary R&D team integrating electrical engineering, biology, medicine, and clinical practice. Leveraging its internationally leading steep pulse ablation technology platform and systematic solutions oriented to clinical needs, it has received funding from a Key Program of the National Natural Science Foundation of China in this field as well as multiple national key R&D and NSFC grants. The company holds fully independent intellectual property rights to IRE technology and has cumulatively filed more than 200 domestic and international invention patents (including 18 PCT applications), and it has twice been granted recognition under the Medical Device Innovation Channel. The company will continue to drive technological innovation and clinical translation, providing patients worldwide with safer, more reliable, less invasive, and more accessible Chinese oncology solutions.

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Official website: www.winonco.com     


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